New topical cream for Actinic Keratosis (AK) works in 7 days without side effects … fact or fiction?

Actinic Keratosis (AK), also sometimes called Solar Keratosis (or sunspots) is a chronic skin condition characterised by a scaly lesion that has the potential to be malignant. Actinic Keratoses tend to occur on sun-exposed areas such as the head and neck and the back of forearms and hands. They are usually less than 1 cm in diameter and often felt as rough, gritty areas even before they become visible. Rough, white surface scale is also usually present.

So what is the issue with AK? Medical practitioners are generally concerned with the potential for AK to become malignant and transform into SCC (Squamous Cell Carcinoma), which is a serious situation. Now we are told that the percentage risk of transformation from AK to SCC is quite low, but who wants to run those odds when we are gambling with our lives and our health, so consumers are always on the lookout for safe ways to treat potentially dangerous AK spots.


There are a number of topical products on the market for AK, but many leave your skin vastly worse than before the treatment. A new topical cream, sold under the brand name ZenaDerm, was released in Australia and New Zealand in 2018 and is based on the anti-tumour properties of Tea Tree Oil and we are told it uses the vasodilation properties of pure Vanilla to deliver the active ingredients trans dermally (under the skin), without side effects.

The product has undergone 5 clinical trials at the University of Kentucky in the USA and according to the manufacturers, ZenaDerm not only clears up AK spots in as little as 7 days, but it does so without side effects. The dermal (skin irritation) scores in clinical trials were so low they were first thought to be errors in the trial results.

Dr David Goldstein, a contributor for NaturalHealthMedia, evaluated ZenaDerm and agreed with the low irritation factor of the product. “This product is certainly low on the irritation scale” he said, “but from my own evaluation it is very effective in clearing up AK in a short amount of time.”

The clinical studies were conducted under the direction of Professor Don Cohen at the University of Kentucky, and Professor Cohen was impressed at the inflammation results of the study. Professor Cohen went on to say “It is rare to see a topical product of this intensity being able to be applied without any visible side effects. While the efficacy of the product has great promise, the lack of side effects (for me) is the most outstanding difference in the product that I have seen, compared to other topical products for the AK category”

ZenaDerm is manufactured in Australia and after an initial test launch in the USA (mid 2018) it was launched in Australia for the 2018/2019 summer. The product comes in a 15 gram airless bottle, quite handy for travel as well.

My Pro’s & Cons – at first glance the product seems expensive, even at the first season reduced rate of $199.00, but on review of other topical products it is actually quite reasonably priced, with other topical products for AK ranging from $275 – $399 per bottle. More recently, prior to summer, the Australian distributors have offered a $50 off-season discount, bringing the price down to $149.00. It seems very easy to apply and seems to work well within the specified time frame (and if it doesn’t work it comes with a full money back guarantee offer). From our testing it also definitely proved to have no side effects that we could see.

So if you suffer AK and want to try a new treatment that is non-invasive. and claimed to be completely free of side effects, we have rate this product as a buy on our reviews conducted so far. Click this link  to buy the product at a $50.00 discount, and pay a maximum of $149.00 per bottle and no shipping costs.

Reporter:  Amy Goodwin for Natural Health Media. For questions or comments
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